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Materials and methods We performed genome wide study of CNVs in epileptic patients by using high density array comparative genome hybridization (CGH) technology for the identification of novel chromosomal aberrations. For this purpose, a cohort of 60 patients suffering with epileptic disorders was recruited. Investigation by array CGH was done for the detection of their chromosomal aberrations. The attained results were analyzed by microarray data analysis software PARTEK and the novelty of CNVs was checked by using Database of Genomic Variants (DGV). Furthermore, array CGH results amplification and deletions were confirmed by quantitative real time PCR.

bmc genomics

Microarray based comparative genome hybridization detects genomic imbalances deletions and duplications in different epileptic patients of Saudi Arabia