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Background Resveratrol (RSV) is a polyphenolic phytoalexin (3, 5, 4’trihydroxystilbene) produced by plants as a protective defense mechanism against pathogens or environmental stress [1]. RSV is found in various plant species such as peanuts, mulberries, Japanese knotweed and skin of grapes. As such RSV is a component of red wine. Interestingly, the prevalence of coronary heart disease (CHD) is comparatively reduced in people from Southern France despite high dietary intake of saturated fats [1-3]. In order to uncork this “French-Paradox”, as well as to identify other potential health benefits of RSV in relation to cancer, infection and inflammation, we studied molecular docking of RSV with known protein structures implicated in health and disease and further dissected the potential molecular networks regulated by RSV.

bmc genomics

Molecular docking of resveratrol with known protein structures as well as high-throughput meta-data analyses uncork the “French Paradox” and its potential “Druggable” targets in humans