English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Kutzneria  is a representative of a rarely observed genus of the family  Pseudonocardiaceae. Kutzneria  species were initially placed in the  Streptosporangiaceae  genus and later reconsidered to be an independent genus of the  Pseudonocardiaceae. Kutzneria albida  is one of the eight known members of the genus. This strain is a unique producer of the glycosylated polyole macrolide aculeximycin which is active against both bacteria and fungi.  Kutzneria albida  genome sequencing and analysis allow a deeper understanding of evolution of this genus of  Pseudonocardiaceae , provide new insight in the phylogeny of the genus, as well as decipher the hidden secondary metabolic potential of these rare actinobacteria.    Results  To explore the biosynthetic potential of  Kutzneria albida  to its full extent, the complete genome was sequenced. With a size of 9,874,926 bp, coding for 8,822 genes, it stands alongside other  Pseudonocardiaceae  with large circular genomes. Genome analysis revealed 46 gene clusters potentially encoding secondary metabolite biosynthesis pathways. Two large genomic islands were identified, containing regions most enriched with secondary metabolism gene clusters. Large parts of this secondary metabolism “clustome” are dedicated to siderophores production.    Conclusions   Kutzneria albida  is the first species of the genus  Kutzneria  with a completely sequenced genome. Genome sequencing allowed identifying the gene cluster responsible for the biosynthesis of aculeximycin, one of the largest known oligosaccharide-macrolide antibiotics. Moreover, the genome revealed 45 additional putative secondary metabolite gene clusters, suggesting a huge biosynthetic potential, which makes  Kutzneria albida  a very rich source of natural products. Comparison of the  Kutzneria albida  genome to genomes of other actinobacteria clearly shows its close relations with  Pseudonocardiaceae  in line with the taxonomic position of the genus.    Electronic supplementary material  The online version of this article (doi:10.1186/1471-2164-15-885) contains supplementary material, which is available to authorized users.

bmc genomics

Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae