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Background   Anopheles sinensis  is an important mosquito vector of  Plasmodium vivax,  which is the most frequent and widely distributed cause of recurring malaria throughout Asia, and particularly in China, Korea, and Japan.    Results  We performed 454 next-generation sequencing and obtained a draft sequence of  A. sinensis  assembled into scaffolds spanning 220.8 million base pairs. Analysis of this genome sequence, we observed expansion and contraction of several immune-related gene families in anopheline relative to culicine mosquito species. These differences suggest that species-specific immune responses to  Plasmodium  invasion underpin the biological differences in susceptibility to  Plasmodium  infection that characterize these two mosquito subfamilies.    Conclusions  The  A. sinensis  genome produced in this study, provides an important resource for analyzing the genetic basis of susceptibility and resistance of mosquitoes to  Plasmodium  parasites research which will ultimately facilitate the design of urgently needed interventions against this debilitating mosquito-borne disease.

Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites