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Duplications and rearrangements of coding genes are major themes in the evolution of mitochondrial genomes, bearing important consequences in the function of mitochondria and the fitness of organisms. Yu  et al . ( BMC Genomics  2008, 9:477) reported the complete mt genome sequence of the oyster  Crassostrea hongkongensis  (16,475 bp) and found that a DNA segment containing four tRNA genes ( trnK 1  ,  trnC ,  trnQ 1   and  trnN ), a duplicated ( rrnS ) and a split rRNA gene ( rrnL5 ') was absent compared with that of two other  Crassostrea  species. It was suggested that the absence was a novel case of "tandem duplication-random loss" with evolutionary significance. We independently sequenced the complete mt genome of three  C. hongkongensis  individuals, all of which were 18,622 bp and contained the segment that was missing in Yu  et al .'s sequence. Further, we designed primers, verified sequences and demonstrated that the sequence loss in Yu  et al .'s study was an artifact caused by placing primers in a duplicated region. The duplication and split of ribosomal RNA genes are unique for  Crassostrea  oysters and not lost in  C. hongkongensis . Our study highlights the need for caution when amplifying and sequencing through duplicated regions of the genome.

"Tandem duplication-random loss" is not a real feature of oyster mitochondrial genomes