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Background  Fatty acid composition has become an important trait in the beef industry in terms of beef flavor and decreasing the circulating concentration of LDL cholesterol. In this study, we examined the association between polymorphisms of six genes,  adipocytes-type fatty acid binding protein  ( FABP4 ),  liver X receptor α  ( LXRα ),  cytochrome b  5  ( Cyt b  5 ),  long-chain acyl-CoA synthetase  ( ACSL )  1 ,  ACSL4  and  diacylglycerol acyltransferase 2  ( DGAT2 ) and fatty acid composition.    Results  Sequence comparisons revealed 14 single nucleotide polymorphisms in six genes. Four of them, I74V and V110M in  FABP4  and G51E and V133I in  LXRα , were nonsynonymous substitutions. The associations between the genotypes and fatty acid compositions were analyzed by using 234 Japanese Black cattle. The genotypes of  FABP4  I74V and  LXRα  V133I were significantly associated with palmitoleic acids (C16:1, P = 0.0086) and linoleic acid (C18:2, P = 0.0121) content in intramuscular fat, respectively.    Conclusion  Our findings suggest that the two polymorphisms of  FABP4  I74V and  LXRα  V133I might be genetic factors in part associated with palmitoleic acid ( FABP4  I74V) and linoleic acid ( LXRα  V133I) composition in intramuscular fat of Japanese Black cattle, respectively. Especially,  FABP4  I74V had highly significant effect (P < 0.01) on C16:1 proportion, indicating that the I/I homozygote exhibited 0.5% higher percentage than V/V homozygote.

Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese Black cattle