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Abstract Background Genomic imprinting is an epigenetic chromosomal modification in the gametes or zygotes that results in a non-random monoallelic expression of specific autosomal genes depending upon their parent of origin. Approximately 44 human genes have been reported to be imprinted. A majority of them are clustered, including some on chromosome segment 11p15.5. We report here the imprinting status of the <it>SLC22A1LS </it>gene from the human chromosome segment 11p15.5 Results In order to test for allele specific expression patterns, PCR primer sets from the <it>SLC22A1LS </it>gene were used to look for heterozygosity in DNA samples from 17 spontaneous abortuses using PCR-SSCP and DNA sequence analyses. cDNA samples from different tissues of spontaneous abortuses showing heterozygosity were subjected to PCR-SSCP analysis to determine the allele specific expression pattern. PCR-SSCP analysis revealed heterozygosity in two of the 17 abortuses examined. DNA sequence analysis showed that the heterozygosity is caused by a G>A change at nucleotide position 473 (c.473G>A) in exon 4 of the <it>SLC22A1LS </it>gene. PCR-SSCP analysis suggested that this gene is paternally imprinted in five fetal tissues examined. Conclusions This study reports the imprinting status of the <it>SLC22A1LS </it>gene for the first time. The results suggest imprinting of the paternal allele of this gene in five fetal tissues: brain, liver, placenta, kidneys and lungs.</p

Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5.