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Background  The lateral line system in zebrafish is composed of a series of organs called neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells, surrounded by accessory cells.    Results  In this report we describe zebrafish  prox1  mRNA expression in the migrating primordium and in the neuromasts of the posterior lateral line. Furthermore, using an antibody against Prox1 we characterize expression of the protein in different cell types within neuromasts, and we show distribution among the supporting cells and hair cells.    Conclusion  Functional analysis using antisense morpholinos indicates that  prox1  activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.

The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line