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Background  Vertebrate classic cadherins are divided into type I and type II subtypes, which are individually expressed in brain subdivisions (e.g., prosomeres, rhombomeres, and progenitor domains) and in specific neuronal circuits in region-specific manners. We reported previously the expression of  cadherin19  ( cad19 ) in Schwann cell precursors.  Cad19  is a type II classic cadherin closely clustered on a chromosome with  cad7  and  cad20 . The expression patterns of  cad7  and  cad20  have been reported previously in chick embryo but not in the developing and adult central nervous system of mammals. In this study, we identified rat  cad7  and  cad20  and analyzed their expression patterns in embryonic and adult rat brains.    Results  Rat cad7 protein showed 92% similarity to chick cad7, while rat cad20 protein had 76% similarity to  Xenopus  F-cadherin. Rat  cad7  mRNA was initially expressed in the anterior neural plate including presumptive forebrain and midbrain regions, and then accumulated in cells of the dorsal neural tube and in rhombomere boundary cells of the hindbrain. Expression of rat  cad20  mRNA was specifically localized in the anterior neural region and rhombomere 2 in the early neural plate, and later in longitudinally defined ventral cells of the hindbrain. The expression boundaries of  cad7  and  cad20  corresponded to those of region-specific transcription factors such as  Six3 ,  Irx3  and  Otx2  in the neural plate, and  Dbx2  and  Gsh1  in the hindbrain. At later stages, the expression of  cad7  and  cad20  disappeared from neuroepithelial cells in the hindbrain, and was almost restricted to postmitotic cells, e.g. somatic motor neurons and precerebellar neurons. These results emphasized the diversity of  cad7  and  cad20  expression patterns in different vertebrate species, i.e. birds and rodents.    Conclusion  Taken together, our findings suggest that the expression of  cad7  and  cad20  demarcates the compartments,   boundaries, progenitor domains, specific nuclei and specific neural circuits during mammalian brain development.

Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system