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Background   Rex1 / Zfp42  has been extensively used as a marker for the undifferentiated state of pluripotent stem cells. However, its function in pluripotent stem cells including embryonic stem (ES) cells remained unclear although its involvement in visceral endoderm differentiation in F9 embryonal carcinoma (EC) cells was reported.    Results  We showed the function of  Rex1  in mouse ES cells as well as in embryos using the conventional gene targeting strategy. Our results clearly indicated that  Rex1  function is dispensable for both the maintenance of pluripotency in ES cells and the development of embryos. However,  Rex1 -/- ES cells showed the defect to induce a subset of the marker genes of visceral endoderm, when differentiated as embryoid body, as found in EC cells.    Conclusion   Rex1  should be regarded just as a marker of pluripotency without functional significance like the activity of alkaline phosphatase.

Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells