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Background  In the vascular system, Notch receptors and ligands are expressed mainly on arteries, with Delta-like 4 (Dll4) being the only ligand known to be expressed early during the development of arterial endothelial cells and capillaries.  Dll4  null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity.    Results  The current detailed analysis of these mutants shows that the arterial defect precedes the initiation of blood flow and that the arterial  Dll4  -/-  endothelial cells proliferate and migrate more actively.  Dll4  -/-  mutants reveal a defective basement membrane around the forming aorta and increased endothelial cell migration from the dorsal aorta to peripheral regions, which constitute the main causes of arterial lumen reduction in these embryos. The increased proliferation and migration of  Dll4  -/-  endothelial cells was found to coincide with increased expression of the receptors VEGFR-2 and Robo4 and with downregulation of the TGF-β accessory receptor Endoglin.    Conclusion  Together, these results strongly suggest that Notch signalling can increase arterial stability and calibre by decreasing the response of arterial endothelial cells to local gradients of pro-angiogenic factors like VEGF.

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli