English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Cdkn1c  encodes an embryonic cyclin-dependant kinase inhibitor that acts to negatively regulate cell proliferation and, in some tissues, to actively direct differentiation. This gene, which is an imprinted gene expressed only from the maternal allele, lies within a complex region on mouse distal chromosome 7, called the IC2 domain, which contains several other imprinted genes. Studies on mouse embryos suggest a key role for genomic imprinting in regulating embryonic growth and this has led to the proposal that imprinting evolved as a consequence of the mismatched contribution of parental resources in mammals.    Results  In this study, we characterised the phenotype of mice carrying different copy number integrations of a bacterial artificial chromosome spanning  Cdkn1c . Excess  Cdkn1c  resulted in embryonic growth retardation that was dosage-dependent and also responsive to the genetic background. Two-fold expression of  Cdkn1c  in a subset of tissues caused a 10–30% reduction in embryonic weight, embryonic lethality and was associated with a reduction in the expression of the potent, non-imprinted embryonic growth factor,  Igf1 . Conversely, loss of expression of  Cdkn1c  resulted in embryos that were 11% heavier with a two-fold increase in  Igf1 .    Conclusion  We have shown that embryonic growth in mice is exquisitely sensitive to the precise dosage of  Cdkn1c .  Cdkn1c  is a maternally expressed gene and our findings support the prediction of the parental conflict hypothesis that that the paternal genome silences genes that have an inhibitory role in embryonic growth. Within the IC2 imprinted domain,  Cdkn1c  encodes the major regulator of embryonic growth and we propose that  Cdkn1c  was the focal point of the selective pressure for imprinting of this domain.

Cdkn1c (p57 Kip2 ) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7