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We gathered the human protein sequences associated to at least one disease or susceptibility to disease, from the RefSeq protein database, using information from the Online Mendelian Inheritance in Man (OMIM) database (morbidmap). These proteins were then used to identify their respective orthologues in zebrafish. The resulting information was compiled, characterised and linked with other zebrafish information such as in-situ and mutant allele data to generate the ZF Human Disease Database (ZFHDD). The zebrafish mutant allele data was used to validate this systematic approach by demonstrating that previously characterised candidate zebrafish proteins/genes have been used to model human genetic conditions.

ZF-Human Disease Database: A Database for Zebrafish Models of Human Genetic Diseases