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Epigenetics, and more specifically DNA methylation is a fast evolving research area. In almost every cancer type, each month new publications confirm the differentiated regulation of specific genes due to methylation and mention the discovery of novel methylation markers. The last decade, high-throughput methodologies are frequently used in the discovery of such methylation biomarkers. Examples of such analyses are re-expression experiments (using the demethylating agent 5-Aza-2′-Deoxycytidine, followed by expression micro-array analysis); CpG microarrays such as the Illumina HumanMethylation27 BeadChip and large scale bisulfite sequencing.

Integrating automated literature searches and text mining in biomarker discovery