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Background  SIN3 is a transcriptional repressor protein known to regulate many genes, including a number of those that encode mitochondrial components.    Results  By monitoring RNA levels, we find that loss of SIN3 in  Drosophila  cultured cells results in up-regulation of not only nuclear encoded mitochondrial genes, but also those encoded by the mitochondrial genome. The up-regulation of gene expression is accompanied by a perturbation in ATP levels in SIN3-deficient cells, suggesting that the changes in mitochondrial gene expression result in altered mitochondrial activity. In support of the hypothesis that SIN3 is necessary for normal mitochondrial function, yeast  sin3  null mutants exhibit very poor growth on non-fermentable carbon sources and show lower levels of ATP and reduced respiration rates.    Conclusions  The findings that both yeast and  Drosophila  SIN3 affect mitochondrial activity suggest an evolutionarily conserved role for SIN3 in the control of cellular energy production.

Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function