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Methods Baseline data of 2,240 solid intermediate-sized nodules (volume 50-500mm) in 1,498 Dutch-Belgian NELSON trial participants were used. Extrapolated volume based on semi-automatic (SA) maximum diameter and mean of maximum transversal and perpendicular diameter were compared to SA volume measurements by Bland-Altman plots. Analyses were repeated by margin (smooth, lobulated, spiculated, and irregular) and shape (spherical or non-spherical). In 100 randomly selected nodules, diameters were measured manually by two independent radiologists, and compared to the SA diameters.

Agreement of diameter- and volume-based pulmonary nodule management in CT lung cancer screening