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Material and methods 60 patients (41 men, 19 women, mean age 61.8 ± 9.4 years) with histopathologically verified lung cancer were included in this retrospective study. For each patient, up to 2 target lesions were quantitatively evaluated in a baseline and two follow-up CT scans (77 lesions, 154 response classifications) by two independent radiologists. Hilar and mediastinal masses, as well as lesions surrounded by atelectasis were excluded. For each lesion a unidimensional diameter measurement, as well as an automated CT-volumetry was performed. In the follow-up studies, the response evaluation was assessed using RECIST compared to volume equivalents of RECIST with converted thresholds (-65/+73%).

Potential influence of automated volumetry on treatment response classifications in lung cancer lesions