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Aim Functional information for appropriate therapy monitoring of advanced targeted therapies is essential, but standard follow up (FU) examinations with computed tomography (CT) still focus on traditional size measurements. Iodine quantification with dual energy CT (DECT) enables additional quantitative assessment of contrast media uptake. Our purpose was to investigate patterns of contrast media enhancement under BRAF inhibitor therapy (BRAF-I) by performing histogram analyses (HA) of iodine maps based on DECT.

Dual-energy CT for therapy monitoring: histogram analyses of iodine maps reveal typical pattern of enhancement