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Background  To compare the efficacy and safety of budesonide/formoterol (Symbicort ® ) with formoterol (Oxis ® ) in the treatment of patients with acute asthma who showed evidence of refractoriness to short-acting β 2 -agonist therapy.    Methods  In a 3 hour, randomized, double-blind study, a total of 115 patients with acute asthma (mean FEV 1  40% of predicted normal) and a refractory response to salbutamol (mean reversibility 2% of predicted normal after inhalation of 400 μg), were randomized to receive either budesonide/formoterol (320/9 μg, 2 inhalations at t = -5 minutes and 2 inhalations at 0 minutes [total dose 1280/36 μg]) or formoterol (9 μg, 2 inhalations at t = -5 minutes and 2 inhalations at 0 minutes [total dose 36 μg]). The primary efficacy variable was the average FEV 1  from the first intake of study medication to the measurement at 90 minutes. Secondary endpoints included changes in FEV 1  at other timepoints and change in respiratory rate at 180 minutes. Treatment success, treatment failure and patient assessment of the effectiveness of the study medication were also measured.    Results  FEV 1  increased after administration of the study medication in both treatment groups. No statistically significant difference between the treatment groups was apparent for the primary outcome variable, or for any of the other efficacy endpoints. There were no statistically significant between-group differences for treatment success, treatment failure or patient assessment of medication effectiveness. Both treatments were well tolerated.    Conclusion  Budesonide/formoterol and formoterol provided similarly rapid relief of acute bronchoconstriction in patients with asthma who showed evidence of refractoriness to a short-acting β 2 -agonist.

Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol