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Background Pain is defined as an unpleasant sensory and emotional experience, associated with a real or potential tissue damage. Chronic pain (CP) can arise from tissue injuries or inflammation (inflammatory pain), or from lesions of the peripheral or central nervous system (neuropathic pain). The purpose of this study was to search proteins potentially involved in the expression or mediation of pain utilizing proteomic techniques, in an animal model of CP obtained by the ligation of the sciatic nerve.

Proteomic research of proteins involved in pain expression in an animal model of chronic pain