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Progress in headache research suggests that migraine pathophysiology involves inherited abnormal brain functions and that the initiation of headache depends on flow of nociceptive signals that originate in pain-sensitive intra- and extra-cranial organs conveyed through peripheral nociceptors to central trigeminovascular neurons. Despite this progress, little is known about the identity of the pain fibers that mediate the initiation phase, or what activates them.

the journal of headache and pain

EHMTI-0354. Abnormal expression of gene transcripts linked to inflammatory response in the periosteum of chronic migraine patients: implications to extracranial origin of headache