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Chronic migraine (CM) affects 2% of the general population with substantial impact on quality of life. Chronic headache with medication overuse prevalence is about 65% in specialised-headache-centres based studies . Medication overuse (MO), by the International Headache Study definition, is different to Medication overuse headache (MOH) . There is no consensus as to whether pharmacological prophylaxis should be initiated once MO has been treated or both could be done simultaneously . Topiramate efficacy was found to be not affected by medication overuse, moreover the PREEMPT data also indicated a similar response between the two groups.

EHMTI-0133. Does medication overuse matter? Response to botulinum toxin type A in chronic migraine in patients with or without medication overuse