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The involvement of hypothalamic nuclei in the pathophysiology of migraine and trigeminal autonomic cephalalgias has been suggested for some time, with dopaminergic mechanisms proposed to play a prominent role. The hypothalamic A11 nucleus is, to date, the only nucleus found to provide a dopamine-mediated inhibitory effect on nociceptive transmission in the trigeminocervical complex.

EHMTI-0237. The A11 hypothalamic nucleus is susceptible to nitric oxide signalling