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Background Disturbances in appetite and sleep contribute to triggering in migraineurs. Neuropeptide Y (NPY), leptin and insulin are involved in hypothalamic appetite and sleep regulation, and pain modulation. The orexinergic system, known to modulate trigeminocervical complex (TCC) nociceptive activation, is reciprocally influenced by NPY, leptin and insulin. Importantly, hypothalamic activation is involved in migraine pathophysiology.

the journal of headache and pain

EHMTI-0287. Peptides involved in sleep and appetite homeostatic regulation and its effects in the modulation of trigeminovascular nociceptive activation