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Methods Twelve healthy women received injection of 1 g acetazolamide or placebo on two separate days in a randomized double-blind crossover study design. We recorded headache on a verbal rating scale from 0-10 during an immediate phase (0-90 min) and a delayed phase (2-12 h). The circumferences of cranial arteries were measured in a blinded fashion using 3T high-resolution magnetic resonance angiography 30 and 60 min after acetazolamide injection.

EHMTI-0165. Acetazolamide infusion induces immediate and delayed headache and intracranial artery dilatation in healthy volunteers