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Results Our data show that CSD induces differential expression of genes involved in inflammatory pathways in both the FHM1 and wild-type mice. However, we identified a gene set that is up-regulated upon CSD specifically in the FHM1 migraine mouse model. Genes from this gene set are involved in inflammatory and interferon-related signaling, and were often found up-regulated in immunestimulated conditions.

the journal of headache and pain

EHMTI-0262. Dysregulation of inflammatory pathways in a familial hemiplegic migraine 1 mouse model after the induction of cortical spreading depression