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Several studies suggest that an increased oxidative stress is a key event in migraine, especially in the form with aura. One of the most efficient first line antioxidant defense system of cells exposed to oxygen is Superoxide Dismutase (SOD) system. The SOD1 gene presents a polymorphism (A/C substitution - rs2234694) resulting in lower serum activitiy in subjects carrying CC genotype. SOD2 gene presents a polymorphism (C/T transition -rs4880 – Ala16Val) which leads to an instable mRNA and reduced transport of the enzyme in TT genotype carriers.

EHMTI-0241. Association between migraine and sod1 and sod2 genes polymorphisms: the biobim study