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Patients with chronic headache who consume large amounts of analgesics are often encountered in clinical practice. Excessive intake of analgesics is now considered to be a cause, rather than simply a consequence of frequent headaches, and as such the diagnosis “medication overuse headache” has been formulated[1]. Despite the prevalence and clinical impact of medication overuse headache the pathophysiology behind this disorder remains unclear and specific mechanism-based treatment options are lacking.

Medication overuse headache is a manifestation of opioid induced hyperalgesia: a neuroimmune hypothesis and novel approach to treatment