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Background  Various health benefits have been attributed to Er-Miao-San (EMS), a traditional Chinese herbal formulation that contains equal amounts of cortex phellodendri ( Phellodendron amurense  Ruprecht) and rhizoma atractylodis ( Atractylodes lancea  D.C). However, its effect on the anti-inflammatory activity in human dermal fibroblasts (HDFs) and the mechanism underlying this effect are unknown.    Results  This study investigated the effects of EMS on TNF-α-induced  MMP-1  expression in HDFs. Our data show that EMS inhibited TNF-α-induced  MMP-1  expression in a concentration-dependent manner. Interestingly, EMS maintained IκB content without inhibiting the phosphorylation of MAPKs, which are well-established upstream kinases of NF-κB. Moreover, EMS reduced the level of nuclear p65 protein in HDFs. Luciferase assay revealed that EMS inhibits the transcriptional activity of NF-κB by stabilizing IκB. Our results show that EMS exerts its anti-inflammatory effect by inhibiting NF-κB-regulated genes such as  IL-1β  and  IL-8 . Moreover, EMS effectively inhibited TNF-α-induced expression of  MMP-1  via the NF-κB pathway.    Conclusions  Taken together, our data suggest that EMS could potentially be used as an anti-inflammatory and anti-aging treatment.

Effects of Er-Miao-San extracts on TNF-alpha-induced MMP-1 expression in human dermal fibroblasts