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In smokers with preserved spirometry, D  LCO is associated with ventilation inhomogeneity arising from peripheral airways. Measurement of D  LCO to screen for early lung function abnormalities in smokers may be suboptimal and could be replaced by MBW. https://bit.ly/3nLmgg1.

Influence of ventilation inhomogeneity on diffusing capacity of carbon monoxide in smokers without COPD