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Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.  We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford–Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.  The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10 −12 ) at  IKZF3 . Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as  IKZF3  ( e.g. ZPBP2 ,  ORMDL3  and  GSDMB ) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at  GSDMB , but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at  IL1RL1 ,  TSLP  and  GSDMB  but not for  IL33 .  Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.

A meta-analysis of genome-wide association studies of asthma in Puerto Ricans