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Coronavirus disease 2019 (COVID-19) is associated with a prothrombotic phenotype characterised by coagulopathy and endothelial dysfunction [1–4]. Following some cases of thrombosis after vaccination, the Oxford–AstraZeneca COVID-19 vaccine (AZD1222) was temporarily suspended by some European countries. The European Medicines Agency concluded that the benefits of the vaccine in combating the COVID-19 outbreak continue to outweigh the risk of side-effects. On 19 March, 2021, Germany reported 13 cases of sinus or cerebral vein thrombosis, with more than 1.6 million AstraZeneca COVID-19 vaccine doses administered. Some of these patients also had a heparin-induced thrombocytopenia (HIT)-like syndrome, which suggests an immunological event as one of the potential origins of thrombosis.

Vaccination against COVID-19: insight from arterial and venous thrombosis occurrence using data from VigiBase