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We are grateful to C. Borland for his comments on our review of the TLNO/TLCO ratio (the ratio of the transfer factor of the lung for nitric oxide versus carbon monoxide) [1] and its clinical applications. Undoubtedly, TLNO, on its own, has a role to play in accessing alveolar function in terms of the membrane diffusing capacity, DM. The calculation of pulmonary capillary volume (Vc), on the other hand, requires a value for HblCO, the specific conductance of blood for carbon monoxide, and there is some doubt about its correct value. The TLNO/TLCO ratio does not require knowledge of HblCO.

TheTLNO/TLCOratio in pulmonary function test interpretation

TheT_LNO/T_LCOratio in pulmonary function test interpretation