Open AccessPerioperative Evaluation of Bleeding Diathesis
Author(s) -
Lawrence Leung
Publication year - 2006
Publication title -
hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 43
eISSN - 1520-4391
pISSN - 1520-4383
DOI - 10.1182/asheducation-2006.1.457
Subject(s) - medicine , clotting factor , perioperative , bleeding diathesis , hemorrhagic diathesis , thrombin , partial thromboplastin time , prothrombin time , prothrombin complex concentrate , surgery , anesthesia , coagulation , gastroenterology , platelet , warfarin , atrial fibrillation
The differential diagnosis of a long APTT with a normal prothrombin time can be due to either a clotting factor deficiency or the presence of an inhibitor, which can be distinguished by using a plasma-mixing study. The various clotting factor deficiency states are reviewed. Clinical bleeding following cardiac bypass surgery due to acquired factor V and thrombin antibodies is also reviewed.
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