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Background.  The leaves of Bersama abyssinica are used for the treatment of diabetes mellitus in folk medicine system of Ethiopia. The present study was done based on the traditional claim of B abyssinica for the treatment of diabetes mellitus.    Methods.  The α-amylase inhibition and antioxidant activities of B abyssinica extracts were evaluated by using 3,5-dinitrosalicylic acid method and diphenyl-2-picrylhydrazyl assay model, respectively. Blood glucose lowering activity of the extracts was studied in 4 animal models; normoglycemic, oral glucose loaded, and streptozotocin-induced diabetic mice models.    Results.  Among the extracts, the crude extract showed the highest α-amylase enzyme inhibition activity with an IC 50 of 6.57 μg/mL. The water fraction showed the strongest antioxidant activity with an IC 50 of 3.43 μg/mL. The crude extract at doses of 200, and 400 mg/kg showed significant ( P &lt; .05) hypoglycemic activity in normoglycemic mice. All doses of the crude extract significantly ( P &lt; .05) reduced blood glucose levels of oral glucose-loaded mice. In streptozotocin-induced diabetic mice models, both the crude and solvent fractions showed a significant ( P &lt; .05) blood glucose lowering effect as compared with the negative control group post 8 hour treatment.    Conclusion.  The results demonstrated the beneficial biochemical effects of B abyssinica extract by inhibiting α-amylase and scavenging the free radicals. The crude extract and solvent fractions of B abyssinica had significant blood glucose lowering effect in all animal models.

journal of evidence-based integrative medicine

Evaluation of In Vivo Antidiabetic, In Vitro α-Amylase Inhibitory, and In Vitro Antioxidant Activity of Leaves Crude Extract and Solvent Fractions of<i>Bersama abyssinica</i>Fresen (Melianthaceae)

Evaluation of In Vivo Antidiabetic, In Vitro α-Amylase Inhibitory, and In Vitro Antioxidant Activity of Leaves Crude Extract and Solvent Fractions ofBersama abyssinicaFresen (Melianthaceae)