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Low-dose 1-µg adrenocorticotropic hormone (ACTH) stimulation test has generally been the test of choice to evaluate adrenocortical function in neonates with suspected ACTH deficiency. There are limited data about its sensitivity in diagnosing central adrenal insufficiency in this age group. We urge caution interpreting cortisol results in the neonatal period and to maintain a high degree of suspicion for false negative testing.

Repeating ACTH Stimulation Test Is Necessary to Diagnose ACTH Deficiency in Neonatal Hypopituitarism With Initial False Negative Result