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Background:   Magnetic resonance imaging (MRI) is an effective tool for objective evaluation after meniscal allograft transplant (MAT). Little is known about the association between MRI features of allograft and clinical outcomes.Purpose/Hypothesis:   To assess the degree and location of signal intensity (SI) as well as the morphology of allografts on MRI after MAT and evaluate the association between clinical outcomes and MRI features in the midterm period. It was hypothesized that a high SI accompanied by a deformed allograft in specific locations on MRI would be associated with inferior clinical outcomes.Study Design:   Cohort study; Level of evidence, 3.Methods:   Included were patients who underwent MAT with fresh-frozen allografts and had &gt;3 years of follow-up with 3.0-T MRI scans. Allograft status was assessed by SI on MRI as grade 0 (normal), grade 1 (globular increased SI not adjacent to the articular surface), grade 2 (linear SI within the meniscus), or grade 3 (increased SI extended to the articular surface). Allograft morphology was assessed by the presence of distorted contours. Clinical outcomes were evaluated using the Lysholm score. The association between clinical outcomes and MRI findings was assessed by multiple linear regression analysis.Results:   A total of 138 patients (156 MAT procedures: 132 lateral, 24 medial) with a mean follow-up period of 55.4 ± 19.9 months (range, 36-110 months) were enrolled in this study. Grade 3 SI was observed in the posterior meniscus root and posterior third of the allograft in 39 (25%) and 62 (39.7%) MATs, respectively. Among the 62 MATs with grade 3 SI in the posterior third of the allograft, 34 (54.8%) were accompanied by distorted allograft contour. The presence of grade 3 SI with distorted contour in the posterior third of the allograft was significantly associated with inferior outcomes (β = –6.5 [95% CI, –12.5 to –0.5]; P &lt; .035), as was the presence of grade 3 SI in the posterior meniscus root (β = –5.5 [95% CI, –10.5 to –0.4]; P &lt; .034).Conclusion:   On MRI evaluation in the midterm period after MAT, grade 3 SIs of the meniscal allograft were observed in about a third of the cases, and the association with clinical outcomes was dependent on the specific location and morphology of the allograft on MRI.

orthopaedic journal of sports medicine

Increased MRI Signal Intensity of Allografts in the Midterm Period After Meniscal Allograft Transplant: An Evaluation of Clinical Significance According to Location and Morphology