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Researchers in an article appearing in Nature used asymptotic(i.e., large sample) chi-square tests in analyzing haplotypes of Y chromosomes using thepolymerase chain reaction applied to genomic DNA from male Israeli, North American, andBritish Jews. The use of classical methods for analyzing extremely sparse contingencytables is frequently done, but with the advent of statistical software capable ofconducting exact tests, researchers should certainly cease relying on outdated methodsfor small sample analyses. A reanalysis was conducted using modern statistical methods.Results and implications for using exact tests are discussed

Statistical Reanalysis of Jewish Priests’ and Non-Priests’ Haplotypes Using Exact Methods