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Background   People living with multiple sclerosis (MS) experience a high symptom burden that interferes with daily functioning. Virtual reality (VR) is an emerging technology with a range of potential therapeutic applications that may include ameliorating the experience of some common MS symptoms.Objective   We tested the feasibility and tolerability of a VR intervention and its preliminary effects on affect.Methods   Participants with MS were recruited to complete a pilot study of eight sessions of VR over four weeks.Results   A total of n = 16 participants with MS completed the study (age range: 28–63). Feasibility goals were met with 100% of the sample completing at least n = 4/8 of their intervention sessions, with a total of 119/128 (93%) completed sessions. Two of the n = 16 participants experienced brief adverse events (balance, vertigo) but these resolved with headset removal and were not otherwise treatment limiting. There was a preliminary indication of overall improved affect from baseline to intervention end, with significantly improved positive affect ( t(15) = −3.19, p = 0.006) and decreased negative affect ( t(15) = 2.25, p = 0.040).Conclusion   VR interventions are feasible, safe, and tolerable for individuals living with MS and may improve affect.

Virtual reality is a feasible intervention platform in multiple sclerosis: A pilot protocol and acute improvements in affect