Open AccessPlasma levels of active Von Willebrand factor are increased in patients with first ST-segment elevation myocardial infarction: A multicenter and multiethnic study
Author(s) -
Bart P. F. Rutten,
A Maseri,
Domenico Cianflone,
Alessandra Laricchia,
N. Cristell,
Alessandro Durante,
Marco Spartera,
Francesco Ancona,
Luca Rosario Limite,
Dayi Hu,
H Li,
NG Uren,
PG de Groot,
PM Mannucci,
Mark Roest
Publication year - 2014
Publication title -
european heart journal acute cardiovascular care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.42
H-Index - 33
eISSN - 2048-8734
pISSN - 2048-8726
DOI - 10.1177/2048872614534388
Subject(s) - myocardial infarction , multicenter study , von willebrand factor , medicine , elevation (ballistics) , cardiology , st segment , platelet , engineering , structural engineering , randomized controlled trial
Von Willebrand factor (VWF), a key player in hemostasis and thrombosis, is released from endothelial cells during inflammation. Upon release, VWF is processed by ADAMTS13 into an inactive conformation. The aim of our study was to investigate whether plasma levels of active VWF, total VWF, ADAMTS13, osteoprotegerin (OPG) and the ratios between VWF and ADAMTS13 are risk factors for first ST-segment elevation myocardial infarction (STEMI).
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