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Many prospective studies have been reported on the associations of blood pressure and blood cholesterol with cardiovascular disease, but few have been large enough to provide reliable estimates of the nature of these associations in different circumstances or to characterize the associations with non-vascular causes of death. Moreover, almost all such reports have related risk to baseline measurements of the risk factor of interest, which can lead to substantial underestimation of the importance of the risk factor due to 'regression dilution' bias.

european journal of cardiovascular prevention and rehabilitation

Collaborative overview (‘Meta-Analysis’) of Prospective Observational Studies of the Associations of Usual Blood Pressure and Usual Cholesterol Levels with Common Causes of Death: Protocol for the Second Cycle of the Prospective Studies Collaboration