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One new tetralone derivative, named aladothalen (1), and one known biogenetically related compound, (3 S,4 S)−3,4,8-trihydroxy-3,4-dihydronaphthalen-1(2 hours)-one (2), were isolated from a deep-sea-derived-fungal Cladosporium sp. HDN17-58. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compound 1 exhibited potent bacteriostatic activity against Bacillus cereus, Mycobacterium phlei and methicillin-resistant coagulase-negative Staphylococci, with a MIC value of 25 µM.

Tetralone Derivatives From a Deep-Sea-Derived Fungus Cladosporium Sp. HDN17-58