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A new veratramine-type alkaloid (1), along with 4 known compounds (2-5), was isolated from the roots of Veratrum maackii var. japonicum (Baker) T. Shimizu. Their structures were elucidated on the basis of NMR and mass spectroscopic data. All compounds were evaluated for their antioxidant activities using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS  + ) and 2,2-diphenyl-1-picrylhydrazyl (DPPH · ) radical scavenging assays. Compounds 1 and 3-5 showed ABTS +  radical scavenging activity with IC 50  values ranging from 15.0 to 85.7 μM.

One New Veratramine-Type Alkaloid From Veratrum maackii var. japonicum and Antioxidative Activities of Isolated Compounds