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Epigallocatechin gallate (EGCG) was structurally modified to obtain EGCG fatty acid esters using an eco-friendly method employing Er(OTf) 3  in 2-MeTHF as the catalyst. The products were purified in short times on a large scale using VERSAFLASH HTFP station on octadecyl-functionalized silica gel. The same Lewis acid showed to be a good catalyst for the synthesis of EGCG peracetated. The EGCG derivatives were assayed for their antioxidant capacity by DPPH assay and by ROS formation using the SH-SY5Y cell line.

Eco-Friendly Synthesis of Lipophilic EGCG Derivatives and Antitumor and Antioxidant Evaluation