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A new series of propargylaminoalkyl derivatives with N-methylpiperazine and morpholine fragments was obtained by modification of the carboxyl group of [3,2b]-indolotriterpenic acids ( N-propargylation, Cu(I) catalyzed Mannich reaction). Cytotoxicity assays demonstrated that oleanane-type conjugate with N-methylpiperazine exhibited high antitumor activity against leukemia cell line SR and non-small cell lung cancer cell line NCI-H460.

Synthesis and Cytotoxicity of 28-N-Propargylaminoalkylated 2,3-Indolotriterpenic acids