English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

M. tuberculosis shikimate kinase ( MtSK) and P. falciparum thioredoxin reductase ( PfTrxR) represent promising drug targets in tuberculosis and malaria therapy respectively. East Indian Sandalwood oil (EISO) has many reported therapeutic benefits including antibacterial and antiplasmodial effects. The aim of this study was to screen EISO for MtSK and PfTrxR inhibition as potential mechanisms of antimycobacterial and antiplasmodial activities. Liquid chromatography-mass spectrometry (LC-MS) functional assays were used to assess MtSK and PfTrxR inhibition. In this study, EISO displayed antitubercular activity against M. tuberculosis H37Rv at MIC value of 0.002% v/v. Subsequently preliminary screening of the MtSK inhibition by EISO showed an IC 50  value of 0.015% v/v. Additionally, EISO presented 90% inhibition of PfTrxR at 0.01% v/v suggesting a potential mechanism of action for reported antimalarial activity.

natural product communications

LC-MS-based Screening of East Indian Sandalwood Oil for <i>Mycobacterium tuberculosis</i> Shikimate Kinase and <i>Plasmodium falciparum</i> Thioredoxin Reductase Inhibitory Activities

LC-MS-based Screening of East Indian Sandalwood Oil for Mycobacterium tuberculosis Shikimate Kinase and Plasmodium falciparum Thioredoxin Reductase Inhibitory Activities