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One new substituted p-terphenyl (1) has been isolated along with the known metabolites; cucurbitacin E 2-O-β-D-glucoside (2) and α-amyrin (3) from ethyl acetate and dichloromethane fractions of fruit extract of Citrullus colocynthis. The structure of the new metabolite was elucidated by combined analysis of 1D ( 1 H and  13 C) and 2D (HSQC and HMBC correlations) NMR and MS spectral data. The known metabolites were characterized by comparison of the spectral data with those reported in literature.

New p-Terphenyl from the Fruit of Citrullus colocynthis (Cucurbitaceae)