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The bulbs of onion ( Allium cepa L.) have long been used as food and dietary supplements in the treatment of various diseases. This study aimed to investigate anti-photoaging activities of fermented onions extract rich in flavonoids such as quercetin and isoquercetin. The fermented onions extract (FOE) effectively suppressed the melanin production by inhibition of tyrosinase expression in B16F10 melanoma cells at a concentration of 100 μg/mL. Besides, the FOE exhibited down-regulation of collagenase-1 expression and up-regulation of type I collagen level in UVB-irradiated HaCaT keratinocyte cells. Hyaluronic acid production was increased to 41.11% (10 μg/mL), 107.78% (100 μg/mL), and 146.67% (200 μg/mL) compared with the UVB-irradiated control by treatment of FOE. Therapeutic attempts with FOE might be useful in preventing or treating melanin pigmentary diseases and UVB-induced wrinkle formation.

Fermented Onions Extract Inhibits Tyrosinase and Collagenase-1 Activities as a Potential New Anti–Photoaging Agent