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Bioactivity-guided fractionation of the woods extract of Artocarpus heterophyllus collected in Vietnam revealed that a new 2-arylbenzofuran, moracin VN (1) together with two known compounds were isolated. Compound 1 possessed the inhibitory activity on tyrosinase with IC 50  value of 0.82 μM, more potent than the positive control kojic acid (IC 50 , 44.6 μM). Compound 1 also showed moderate inhibitory activity on xanthine oxidase with IC 50  value of 22.8 μM. The kinetic study of tyrosinase was performed on moracin VN (1) showed non-competitive inhibition with K i  value of 2.40 μM.

Moracin VN, A New Tyrosinase and Xanthine Oxidase Inhibitor from the Woods of Artocarpus heterophyllus