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Three compouds, (+)-butyrolactone IV (1), butyrolactone I (2) and terrelactone A (3) were isolated from the fungus Aspergillus terreus associated with Apostichopus japonicus from the Yellow Sea in China; their structures were elucidated by spectral methods. Compounds 1 and 2 were shown to have moderate antiangiogenesis activity when tested using the zebrafish assay. This is the first report of butyrolactones with antiangiogenesis activity.

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Isolation and Characterization of Antiangiogenesis Compounds from the Fungus <i>Aspergillus terreus</i> Associated with <i>Apostichopus japonicus</i> Using Zebrafish Assay

Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay